Dr Smith completed his PhD in the Microbiology and Immunology Department at the University of Melbourne, Australia. He then joined Rajiv Khanna at the QIMR Berghofer Medical Research Institute, Brisbane, Australia, to develop adoptive cell therapy approaches for viral associated diseases. His work has focused heavily upon process development of autologous therapies for immunocompromised patients and cancer patients and in defining correlates of potency following treatment. This work has been translated into multiple clinical trials in head and neck cancer, brain cancer, organ transplant recipients and multiple sclerosis patients. This work has now been licenced for commercial development by Atara Biotherapeutics, where Dr Smith works as a consultant.